Division of Hemostasis

Heads of the Division: Adrienne Kerényi MD, PhD, Zsuzsanna Bereczky MD, PhD

The Division of Hemostasis started its work in 1978 when the department was founded by the University. Diagnostic tools in the field of hemostasis have been increased continually and significantly during the past years and now this unit performs approximately 250,000 analyses per year. The majority of the samples arrive from different clinics of the Medical and Health Science Center and we also receive samples from other hospitals and primary care centers from all over Hungary. Besides screening tests of blood coagulation (prothrombin time, APTT, thrombin time) we have panels for investigating haemorrhagic diathesis including measurements of coagulation factor activities for diagnosis of coagulopathies. The quantitative UV kinetic factor XIII activity determination deserves special importance since the assay was developed in our department, as well as the ELISA method for measurement the factor XIII antigen level. Platelet function disorders are also investigated in our unit. For this reason we perform screening tests of platelet function (bleeding time, PFA-100 global platelet function analysis) and platelet aggregation and secretion studies induced by different agents. Both functional (ristocetin cofactor activity) and antigen tests are available for diagnosis of von Willebrand disease. Besides the diagnosis of haemorrhagic diathesis we also perform diagnosis of thrombophilias. Our thrombophilia panel includes analysis of activated protein C (APC) resistance, protein C and S and antithrombin deficiencies, detection of lupus anticoagulant and titration of anticardiolipin antibodies.The majority of haemostasis tests with exception of ELISA methods and platelet aggregation are performed on different coagulometers (Stago STA Compact, Stago STA-R, Sysmex CA 1500, Sysmex CA 540).