Division of Therapeutic Drug Monitoring
Head of Division: Béla Nagy, MD, PhD
Chief technologist: Mária Csobán
Therapeutic drug monitoring (TDM) was started at our department in the 1980s. Nowadays, the levels of 9 different drugs are determined with an annual rate of over 8000 analyses. TDM is absolutely necessary when the therapeutic range for a particular drug is quite narrow. The examination is clinically indicated when the required therapeutic effect is missing or when there is a serious doubt for overdosing. It is quite important to be aware of the concentration of drugs in these circumstances while clinical symptoms of under- and over-dosing may be quite similar. The levels of the following drugs are measured at our division when used in the treatment of epilepsy (carbamazepine, valproic acid), administered as immunosuppressive drugs (cyclosporine, sirolimus, tacrolimus and everolimus) and others like digoxin, theophylline and methotrexate. The analyses are carried out on Abbott Architect analyzer based on chemiluminescent microparticle immunoassay (CMIA) and Abbott TDx analyzer by using fluorescent polarization immunoassay (FPIA) method. The measurement of carbamazepine, digoxin, theophylline, methotrexate, valproic acid and cyclosporine is offered on a 24-hour basis.